donepezil hydrochloride

Mechanism of action: Blocks the enzyme acetylcholinesterase. Donepsil is a non-competitive, reversible specific inhibitor of acetylcholinesterase that increases extracellular acetylcholine.

Drug metabolism: The bioavailability of the drug is 100%. Donepsil is well absorbed from the gastrointestinal tract and its maximum plasma concentration is reached 3-4 hours after administration. 96% of dopezil binds to plasma proteins, especially albumin. Donepezil is metabolized in the liver by cytochrome P450, 3A4, and 2D6 isoenzymes to four major metabolites, two of which are active. Steady-state plasma concentrations are reached 3 weeks after the start of treatment. Excretion of the drug and its metabolites is predominantly in the urine (79%) and to a lesser extent (21%) in the feces. The elimination half-life of dopezil is 70 hours

Side effects: nausea, vomiting, diarrhea, fatigue, insomnia, dizziness, anorexia, weight loss, gastric and duodenal ulcers, muscle cramps, tremor, conduction disorders of the heart, bradycardia, extrapyramidal effects of depression, abnormal skin behavior, zinc Skin discoloration and liver disorders, Muscle cramps, Sweating, Urinary tract infection and Respiratory tract infection